Pharmacies & Distribution
SPRAVATO® follows a restricted, closed-distribution model under the FDA's REMS program. Here's exactly how it gets from manufacturer to patient — and the two acquisition pathways your clinic may use.
Under its FDA-required Risk Evaluation and Mitigation Strategy (REMS), SPRAVATO® must be shipped from a certified pharmacy directly to a certified treatment site and administered there under provider supervision. It's a restricted, closed-distribution drug — a tightly controlled exception to how most medications move through the supply chain.
Clinics typically get SPRAVATO® in one of two ways:
The patient's insurer processes the drug under the pharmacy benefit. A specialty pharmacy then ships the medication — dispensed for that specific patient — directly to the clinic for the scheduled appointment.
The clinic purchases and stocks SPRAVATO® from an authorized distributor, administers it, and then bills the patient's medical benefit after the visit.
National, mail-order specialty pharmacies that ship SPRAVATO® directly to certified clinics. There are no walk-in Texas storefronts for SPRAVATO® — your clinic coordinates the pharmacy fulfillment for you.
Partial list of REMS-certified pharmacies (per Janssen, valid as of 2026). For others, call the SPRAVATO REMS Program at 1-855-382-6022.
For clinics using the buy-and-bill pathway, SPRAVATO® is available through Janssen's authorized specialty distributors:
New SPRAVATO® treatment centers often weigh both pathways during setup. Specialty pharmacy reduces inventory risk and upfront cost; buy-and-bill can simplify scheduling and revenue cycle. Many practices use a mix depending on payer mix and patient benefits.